Amyotrophic Lateral Sclerosis (ALS) Clinical Research Trials

Active

Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year

  • Status: No Longer Enrolling
  • Sponsor: Cytokinetics
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Cytokinetics (CY 4031): A Phase 3, Open-Label Extension Study of Tirasemtiv for Patients with Amyotrophic Lateral Sclerosis (ALS) Who Completed Vitality-ALS (CY 4031), Dallas, Texas, October 2016 to present

  • Status: No Longer Enrolling
  • Sponsor: Cytokinetics

Analysis of Transcriptional Changes in Blood Samples from Patients with Neurologic Diseases. Sponsor: Neurologix Foundation

  • Status: No Longer Enrolling
  • Sponsor: Neurologix Foundation, Dallas, Texas
  • Date: January 2017

Speech Movement Patterns of Individuals with Amyotrophic Lateral Sclerosis

  • Status: Enrolling
  • Sponsor: An NIH-funded project that is being conducted at the University of Texas at Dallas in collaboration with Texas Neurology. The goal of this study is to advance the diagnosis, assessment, and treatment of speech motor impairment due to ALS using novel, computational approaches.

A Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in the Treatment of Subjects With Amyotrophic Lateral Sclerosis

  • Status: Enrolling
  • Sponsor: Mallinckrodt
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A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)

  • Status: Enrolling
  • Sponsor: Cytokinetics.
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Completed

ALS COSMOS (ALS Cohort Study of Multicenter Oxidative Stress)

  • Status: Completed 2016
  • Sponsor: National Institute of Health (NIH)

Biogen Idec Evidera ALS Study: Qualitative Investigation of Signs and Related Functional Decline in Patients with Amyotrophic Lateral Sclerosis(ALS)

  • Status: Completed 2015
  • Sponsor: Biogen Idec, Inc.

A Study to Explore the Safety and Tolerability of Acthar in Patients with Amytrophic Lateral Sclerosis

  • Status: Completed 2015
  • Sponsor: Questcor Pharmaceuticals
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Cytokinetics Phase IIb, Multi-National, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of CK-2017357 in Patients with Amyotrophic Lateral Sclerosis (ALS)

  • Status: Completed 2014
  • Sponsor: Cytokinetics
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Analysis of Transcriptional Changes in Blood Samples from Patients with Neurologic Disease

  • Status: Completed 2013
  • Sponsor: Baylor Research Institute

An Open-Label, Multicenter, Extension Study to Evaluate the Long-Term Safety and Efficacy of Dexpramipexole (BIIB050) in Subjects With Amyotrophic Lateral Sclerosis (ENVISION)

  • Status: Completed 2013
  • Sponsor: Biogen
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Northeast ALS (NEALS) Consortium: The Upper Motor Neuron Disease (UMND) Pilot Registry

  • Status: Completed 2013

Clinical Trial with Ceftriaxone in Subjects with ALS(Phase III)

  • Status: Completed 2011
  • Sponsor: NIH, NINDS
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TIV(Tracheostomy with invasive ventilation) for Patients with ALS in Japan and the USA: A Comparitive Study

  • Status: Completed 2011
  • Sponsor: Columbia University and the MDA

A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Safety and Efficacy of Dexpramipexole in Subjects With Amyotrophic Lateral Sclerosis (EMPOWER)

  • Status: Completed 2011
  • Sponsor: Biogen
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A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy, and to Determine the Pharmocokinetics of Two Doses of AVP-923 (Dextromethrophan/Quinidine) in the Treatment of Pseudobulbar Affect (PBA) in Patients with Amyotrophic Lateral Sclerosis and Multiple Sclerosis

  • Status: Completed 2010
  • Sponsor: Avanir Pharmaceuticals
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A Multicenter, Double-Blinded, Placebo-Controlled, Study to Investigate the Safety and Efficacy of Lithium with Riluzole in Volunteers with Amyotrophic Lateral Sclerosis

  • Status: Completed 2009
  • Sponsor: NIH/NINDS, ALSA and The ALSA Society of Canada Clinical Trials Research Network
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ALS Patient Care Database

  • Status: Completed 2007
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Collection of Data and Biomaterial for Repository Banking to Facilitate Research into the Etiology of ALS and Related Motor Neuron Diseases

  • Status: Completed 2007
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Centers for Disease Control IRB - Protocol 5923.0 – “Proposal for the State and Metropolitan Area-Based ALS Surveillance”

  • Status: Completed
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Texas Department of State Health Services IRB – # 10-036 – “Texas Amyotrophic Lateral (ALS) Surveillance Activity”

  • Status: Completed
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